CHIMERIC STUDIES OF THE RECEPTOR SUBTYPES

In an attempt to better understand the varying degrees of selectivity in the interaction between opioid receptors and their multiple ligands, chimeric receptors have been generated and tested with several ligands. We have tabulated many of the published results and separated them into the categories below. Click on the cited authors to view the results of their studies. Each article's Medline abstract is linked from its respective page.


Delta/Kappa Chimeras

Kappa/Mu Chimeras

Mu/Delta Chimeras
Meng et al., (1996)
Eur. J. Pharmacol. 311, 285-292

Meng et al., (1995)
J. Biol. Chem. 270, 12730-12736

Kong et al., (1994)
Proc. Natl. Acad. Sci. USA 91, 8042-8046

Kong et al., (1994)
Regul. Pept. 54, 155-156

 Hjorth et al., (1996)
Mol. Pharmacol. 50, 977-984

Zhu et al., (1996)
FEBS Lett. 384, 198-202

Hjorth et al., (1995)
Mol. Pharmacol. 47, 1089-1094

Xue et al., (1995)
J. Biol. Chem. 270, 12977-12979

Minami et al., (1995)
FEBS Lett. 364, 23-27

Wang et al., (1994)
J. Biol. Chem. 269, 25966-25969

Xue et al., (1994)
J. Biol. Chem. 269, 30195-30199

 Meng et al., (1996)
Eur. J. Pharmacol. 311, 285-292

Zhu et al., (1996)
FEBS Lett. 384, 198-202

Zhu et al., (1996)
J. Biol. Chem. 271, 1430-1434

Li et al., (1996)
Eur. J. Pharmacol. 300, R1-R2

Valiquette et al., (1996)
J. Biol. Chem. 271, 18789-18796

Varga et al., (1996)
Mol. Pharmacol. 50, 1619-1624

Minami et al., (1996)
Mol. Pharmacol. 50, 1413-1422

Fukuda et al., (1995)
J. Biol. Chem. 270, 6702-6709

Wang et al., (1995)
Proc. Natl. Acad. Sci. USA 92, 12436-12440

Onogi et al., (1995)
FEBS Lett. 357, 93-97